The Epigenetic Relation Between Substance Abuse and Mental Health Disorders
Brigham Battiston, Isabella Bonefeld, Julia Borowiak, Caterina Milan, Carlota Pinto and Misa Shirakata
This review examines how alcohol and opioids modify the epigenome in key brain regions, contributing to anxiety, depression, post-traumatic stress disorder and addiction vulnerability. It also summarises evidence from animal and human studies demonstrating that these epigenetic alterations can be transmitted across generations.