Neuroprotective effect of resveratrol on Epac-1/Rap-1 signaling pathway in ischemic stroke rats
Yue Zou
ObjectiveTo evaluate the neuroprotective effect of resveratrol (Res) and elucidate its underlying mechanism in a rat model of cerebral ischemia–reperfusion injury.MethodsAdult male Sprague–Dawley rats received intraperitoneal Res (40 mg/kg/day) for three consecutive days, followed by transient middle cerebral artery occlusion/reperfusion (MCAO/R). Animals were randomly divided into Sham, MCAO/R, and Res groups. Neurological function was evaluated 24 h after reperfusion. Cerebral infarct volume w