The history and function of a circular RNA
Nikolaus Rajewsky
Nature Communications, Published online: 27 April 2026; doi:10.1038/s41467-026-71822-0 In this paper, the authors review how the circular RNA Cdr1as and its interacting non-coding RNAs regulate neuronal stress responses and synaptic activity, highlighting general principles of RNA-based regulatory mechanisms and their relevance for brain function, disease, and therapy.