Nature Communications, Published online: 15 July 2026; doi:10.1038/s41467-026-75471-1 Bifunctional glycosylases repair oxidized DNA via glycosylase and lyase reactions. Here, authors define an OGG1/NTH1 mechanism conserved across domains of life and show that OGG1 agonists accelerate product release, enabling therapeutic targeting of DNA repair.