Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant Mycobacterium tuberculosis
Jeremy M. Rock
Nature Microbiology, Published online: 19 May 2026; doi:10.1038/s41564-026-02357-9 A common rifampicin-resistance mutation in Mycobacterium tuberculosis alters transcription and creates new metabolic vulnerabilities through transcription attenuation, revealing potential targets to combat drug-resistant tuberculosis.