tRNA-Derived Small RNAs (tsRNAs): Functions, Disease Associations, and Research Applications
mybcs
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNAs (sncRNAs) generated from precursor or mature tRNAs through specific cleavage by ribonucleases such as Angiogenin (ANG), Dicer, and RNase Z [1,4]. Once regarded as random degradation products, tsRNAs are now recognized as critical regulators of gene expression, with significant roles in physiological and pathological processes, including cancer, cardiovascular diseases, and digestive tract disorders...