IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice

Nature Microbiology, Published online: 03 June 2026; doi:10.1038/s41564-026-02375-7 Single-cell studies uncovered specialization of epithelial cells in intestinal defence. The epithelial cell-targeting cytokine IL-22 protected mice from cholera by promoting the genesis of mucus-secreting cells.