Integrative analysis identifies DCBLD2 and immune-related biomarkers for major depressive disorder: evidence from human peripheral blood, post-mortem brain, and rat models
Xuehua Zhang
ContextMajor depressive disorder (MDD) is a prevalent mental illness, and inflammatory processes are considered a pivotal component of the pathogenesis of MDD. This study aims to identify novel biomarkers associated with the development of MDD and to elucidate the underlying immunological mechanisms.MethodsMendelian randomization (MR) studies confirmed that two inflammatory cytokines are related to MDD. Subsequently, MDD-related transcriptomic datasets were retrieved from the Gene Expression Omn