Proteins with the HAEE tetrapeptide motif as potential targets for beta-amyloid
Vladimir A. Mitkevich (mitkevich@gmail.com)
Proteins with the HAEE tetrapeptide motif as potential targets for beta-amyloid
DOI:
https://doi.org/10.18413/rrpharmacology.11.1046Abstract
Introduction: Beta-amyloid (Aβ) is involved in numerous physiological and pathophysiological processes and is one of the key players in the pathogenesis of Alzheimer’s disease. Aβ interacts with the 35-HAEE-38 site of the α4 subunit of the α4β2 nicotinic acetylcholine receptor. The synthetic tetrapeptide HAEE effectively inhibits the aggregation of...