Efficacy of Pam3CSK4 as a cross-species adjuvant for polysaccharide vaccines in humanized mouse and non-human primate models

Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74194-7 Polysaccharide vaccines are crucial to immunize against bacterial infections but require efficacious adjuvants to induce protective immune responses. Here the authors explore the use of Pam3CSK4 as an adjuvant for polysaccharide vaccines in mouse and non-human primate models.