Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis

Nature Communications, Published online: 15 August 2026; doi:10.1038/s41467-026-76688-w Gene expression profiling of diverse cell types from postmortem human brains is challenging. Here, the authors present a versatile spatial transcriptomic approach to uncover the molecular signatures of appetite-regulating AgRP and POMC neurons.