BackgroundHispidulin is a bioactive flavonoid with promising antioxidant and anticancer properties; however, its poor aqueous solubility and stability limit its usage in therapeutic application. This study aimed to develop a suitable nanocarrier system to enhance its bioavailability and biological efficacy.MethodsHispidulin-loaded sodium carboxymethyl cellulose nanoparticles (HIS-CMC NPs) were synthesised via ionic gelation. Physicochemical characterisation was performed using UV–Vis, FTIR, XRD,