NAT10 maintains stem cell homeostasis by mitigating mRNA decay through an ac 4 C-independent mechanism
Fang Wang
Nature Cell Biology, Published online: 04 May 2026; doi:10.1038/s41556-026-01949-1 Li, Huo, Zhang, Liu and colleagues report that the transcripts of genes involved in haematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N4-acetylcytidine catalytic activity.