Enhanced therapeutic potential of paeoniflorin and vitamin B12 in intracerebropeduncle ethidium bromide-induced multiple sclerosis-like pathology
Acharan S. Narula
The study investigates the neuroprotective potential of paeoniflorin (PNN) in mitigating the multifaceted pathology of multiple sclerosis (MS) in an ethidium bromide-induced (EBRO) rat model. A comprehensive approach utilizing in silico, in-vitro, and in-vivo methodologies reveals that PNN targets key molecular pathways implicated in MS, including the GDNF/GFRA1/RET/AKT/ERK1/2/GSK3-Beta signaling cascade. PNN (50 mg/kg, 100 mg/kg, p.o.) administration, both as monotherapy and in combination with