Extremely low dose norepinephrine in treatment of refractory chronic cluster headache: two case reports and literature review
Enxiang Tao
BackgroundRefractory chronic cluster headache (rCCH) is a severe form of trigeminal autonomic primary headache that often resists conventional pharmacological treatment, resulting in significant impairment in patients’ quality of life. Identifying effective strategies to reduce attack frequency and shorten cluster periods remains a crucial clinical challenge.Case presentationTwo cases of rCCH who had suffered from recurrent paroxysmal headaches for several decades were reported. Both had receive