Nature Communications, Published online: 08 September 2026; doi:10.1038/s41467-026-76761-4 MYC can be transcriptionally regulated by distal super-enhancers (SEs) in cancers. Here, the authors show that MYC, along with ETS2 and FOXP1, form a core regulatory circuit that controls SE-driven transcription in colorectal cancer.
A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer
Xing-Sheng Shu