RNA imbalance as a hallmark of cellular ageing
Kevin Rhine
Nature Cell Biology, Published online: 12 May 2026; doi:10.1038/s41556-026-01946-4 This Perspective highlights the failures of an ageing cell in properly maintaining mRNA health at the various steps of the mRNA life cycle that result in vulnerability to disease, pointing to RNA imbalance as an emerging hallmark of cellular ageing.