Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes
Jessica Zucman-Rossi
Nature Communications, Published online: 19 May 2026; doi:10.1038/s41467-026-73212-y Precision oncology for hepatocellular carcinoma (HCC) remains challenging due to the high diversity of HCC at the clinical and molecular levels. Here, the authors employ an integrative multi-omics approach to identify and characterize nine molecular subtypes and explore their biological and clinical significance via p53/WNT scoring, immune infiltration analyses, and in vivo models.