Multi-omics Mendelian randomization identifies mitochondrial genes associated with immune microenvironment signatures in endometriosis
Fuminori Taniguchi
BackgroundEndometriosis is a complex gynaecological disorder that affects 10%–15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in endometriosis pathogenesis, the causal relationships between mitochondrial genes and endometriosis remain unclear. This study aims to elucidate these relationships through multiomics bioinformatics analysis and experimental validation.MethodsWe analysed 1,133 mito