Licochalcone A mitigates cisplatin-induced nephrotoxicity by inhibiting ferroptosis and mitochondrial dysfunction via the Nrf2/GPX4 axis
Xinyu Wang
BackgroundCisplatin-induced nephrotoxicity is a major dose-limiting complication of chemotherapy. However, effective protective strategies remain limited. Licochalcone A (LicoA), a flavonoid isolated from Glycyrrhiza inflata, exhibits multi-target bioactivity against oxidative stress, inflammation, and metabolic disorders.MethodsIn vivo murine cisplatin-induced model and in vitro HK-2 cells were employed. HE/Masson staining, renal function, oxidative stress, ferroptosis markers (Fe2+, GSH, MDA,