Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein

Nature Communications, Published online: 27 April 2026; doi:10.1038/s41467-026-71729-w Glycogen serves as an intracellular energy storage polymer while some bacteria also produce structurally diverse extracellular α-glucans. Here, the authors establish the molecular basis of phosphorylation and allosteric regulation of glycogen phosphorylase by histidine phosphocarrier protein HPr.