Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids
Aditya M. Kunjapur
Nature Communications, Published online: 23 May 2026; doi:10.1038/s41467-026-73618-8 Genetic code expansion can be limited by the need to supply non-standard amino acids. The authors design bacteria that perform integrated steps of converting supplemented aldehydes to L-phenylalanine derivatives and incorporating them within proteins.