Real-time visualization of collagen assembly uncovers metastable properties in hierarchical organization

Lujia Zhang
Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-71205-5 Using time-resolved cryo-EM, this study captures fibrillar collagen assembly as it matures from a metastable to a stable state, shedding light on tissue maintenance and disease-linked defects.