Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction
Weina Liu
In recent years, the prevalence of myopia has sharply increased in East Asia, emerging as a major public health issue. This study aimed to identify genetic risk factors for myopia progression and to develop polygenic risk score (PRS) models to predict myopia progression risk. Genotyping was performed using the Asian Screening Array chip among 294 Chinese adolescents who completed a 2-year follow-up. A two-stage (discovery cohort: N = 176; replication cohort: N = 118) genome-wide association stud