Hepatology

In this study, GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a lower risk of major adverse liver and cardiovascular outcomes compared with either agent alone among patients with MASLD and T2D.

Background & Aims: Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive liver disease that poses significant public health challenges. Although liver biopsy remains the gold standard for diagnostic and prognostic use in patients with MASH, its invasiveness limits its practical application in routine care and large-scale trials. This narrative review explores the growing ro…

Background: This randomized controlled trial (RCT) evaluated the efficacy and safety of Therapeutic plasma exchange (TPE) versus standard medical therapy (SMT) in ACLF. Methods: In this single-center, open-label RCT (February 2022-March 2025), we randomly (1:1) assigned 194 adult patients (aged 18-60 y) with ACLF (European Association for the Study of the Liver-Chronic Liver Failure Consortium [E…

Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) progresses from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), yet its therapeutic development has been hampered by pathological complexity and heterogeneity. Methods: Bulk RNA-seq and diet-induced MASLD mouse models were employed to explore RNF128 expression patterns in MASLD liv…

Background and Aims: Acute liver failure (ALF) is a life-threatening disease with high mortality rate and limited treatment options. Neutrophils rapidly infiltrate the injured liver, yet their functional heterogeneity and regulatory mechanisms remain poorly understood. We aimed to identify pathogenic neutrophil subsets in ALF and identify potential therapeutic targets. Approach and Results: Singl…

Taken together, FOXM1 is activated in hepatocytes in response to EtOH through a mechanism that involves PKCε, MEK/ERK, cyclin D1-CDK4/6, PIN1, and GRN. Targeting this pathway may represent a novel therapeutic strategy for ALD.

GAPs are central to gut-liver homeostasis. Mucin-2 deficiency enhances GAP formation and confers protection against ALD, whereas GAP closure exacerbates disease. Targeting GC-specific mAChR4 to restore GAPs represents a promising therapeutic strategy for ALD.

In summary, our B-BEST platform provides resources for delineating the heterogeneous landscape of HBV infection, identifying host determinants and microenvironmental factors that govern viral replication and persistence, and highlighting hepatocyte proliferation as a potential clearance mechanism for antiviral therapy.

CORE and LiverRisk are the most discriminative routine blood-based tools for predicting long-term cirrhosis-related morbidity in the community. When referrals are limited, a higher-threshold CORE-only strategy may outperform a sequential CORE-LiverRisk approach.

While DNA sequencing demonstrates superior sensitivity in detecting clinically relevant variants, liver RNA sequencing significantly enhances genetic diagnosis mainly by revealing aberrant splicing and allele-specific expression. These findings suggest that RNA sequencing is an essential complement to DNA sequencing.

HSCs exhibit dual roles contingent on disease context: in MASH with moderate inflammation, they maintain homeostasis, whereas in massive CCl 4 -driven injury, activated HSCs promote fibrogenesis. ECM1 enforces HSC quiescence and facilitates fibrosis resolution. Anti-fibrotic therapies based on general HSC ablation may be harmful.

INTRODUCTION Fibrolamellar carcinoma (FLC) is a rare primary liver cancer with distinctive histology, molecular biology, and clinical presentation that predominantly affects adolescents and young adults. Its characteristic histology was first described by Edmondson in 1956 following resection of a liver carcinoma from a 14-year-old patient.1 It was subsequently described as a distinct clinical an…

Participation in individualized nutrition-focused telemedicine care was associated with significantly lower incidence and risk of new-onset MASLD, MASH, and advanced liver disease. These findings support lifestyle-first interventions that is potentially scalable to reduce liver disease burden in adults with T2D and obesity.

STEAP4 is not essential during the early injury phase but plays a critical role in liver regeneration by maintaining lysosomal iron homeostasis and function after APAP overdose. Targeting STEAP4-mediated endolysosomal iron overload may open new therapeutic avenues for AILI.

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is a major global health burden, ranking sixth in incidence and third in cancer-related mortality. Despite therapeutic advances, treatment options for advanced liver disease and HCC are limited and strategies to prevent HCC development are lacking. To address the urgent need for preventive strategies, we identified aripipr…