Pathogenic Ifit1+ neutrophils driven by IRF7 promote liver injury and represent a therapeutic target in acute liver failure

Background and Aims: Acute liver failure (ALF) is a life-threatening disease with high mortality rate and limited treatment options. Neutrophils rapidly infiltrate the injured liver, yet their functional heterogeneity and regulatory mechanisms remain poorly understood. We aimed to identify pathogenic neutrophil subsets in ALF and identify potential therapeutic targets. Approach and Results: Single-cell RNA sequencing of murine ALF models revealed conserved expansion of Ifit1⁺ neutrophil subset a