Host-viral interaction of HBV infection revealed by single-cell transcriptome jointly profiling the viral replication state
Yanfang Huang·Chao Qiu·Jinhang He·Rongshan Fan·Yongping Liu·Miaoqu Zhang·Zunguo Du·Zhongliang Shen·QuanBao Zhang·Xiaomu Hu·Caixia Zheng·Zhang Xia·Shengran Jiang·Ning Jiang·Wenqi Zhu·Jingshen Wang·Zaoxu Xu·Renjie Liao·Luyang Zhao·Yu Zhang·Jianming Zheng·Yuxian Huang·Jiming Zhang·Guojun Li·Zhengxin Wang·Qiran Zhang·Wenhong Zhang·Hongyuan Xue
In summary, our B-BEST platform provides resources for delineating the heterogeneous landscape of HBV infection, identifying host determinants and microenvironmental factors that govern viral replication and persistence, and highlighting hepatocyte proliferation as a potential clearance mechanism for antiviral therapy.