RNF128 aggravates metabolic dysfunction-associated steatotic liver disease progression via stabilization of SCD1
Lei Cao·Cheng Zhang·Chaofan Wang·Changhao Liu·Wenqian Qi·Ruiqing Ren·Jie Zhang·Shuting Yu·Qian Li·Liangyu Cai·Xinyu Zhang·Xiaohong Wang·W H Sui·Meng Zhang·Wei Yang
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) progresses from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), yet its therapeutic development has been hampered by pathological complexity and heterogeneity. Methods: Bulk RNA-seq and diet-induced MASLD mouse models were employed to explore RNF128 expression patterns in MASLD livers. Hepatic RNF128 expression was characterized in Single-cell RNA sequencing (scRNA-seq) and lipoto