Forkhead box protein M1 network induction and crosstalk drives the development of alcohol-associated liver disease
Bing Yang·Shelly C. Lu·Brent Beadell·G Zhang·Takashi Tsuchiya·Maria Lauda Tomasi·Ting Liu·Heping Yang·Jyoti Chhimwal·George Zhang·Sonal Sinha·Liqing Lu·Lucía Barbier-Torres·Jiaohong Wang
Taken together, FOXM1 is activated in hepatocytes in response to EtOH through a mechanism that involves PKCε, MEK/ERK, cyclin D1-CDK4/6, PIN1, and GRN. Targeting this pathway may represent a novel therapeutic strategy for ALD.