Human Reproduction

Abstract STUDY QUESTION Does the human ovary possess the enzymatic machinery required for local corticosteroid synthesis during follicular development? SUMMARY ANSWER The human ovary exhibits dynamic corticosteroid metabolism during follicular development and expresses enzymes consistent with local corticosteroid synthesis. WHAT IS KNOWN ALREADY Cortisol is a systemic glucocorticoid that binds to…

ChiCTR2300077490.

N/A.

This study was supported by the Fonds National de la Recherche Scientifique de Belgique (T.0004.20 to H.V. and C.A.A.), the Novo Nordisk Foundation (NNF21CC0073729, reNEW to F.W., H.C., and S.M.C.S.L.), the Dutch Organization for Health Research and Development (ZonMW PSIDER-2021-10250022120001 to S.M.C.S.L.), and the China Scholarship Council (CSC 202008450034 to F.W., CSC 202008320362 to H.C.).…

N/A.

Not applicable.

The study is registered at ClinicalTrials.gov: NCT04748874.

N/A.

Treatment of idiopathic male infertility has traditionally relied on the empirical use of oral agents such as clomiphene citrate and aromatase inhibitors, often prescribed without rigorous endocrine phenotyping. The newly proposed APHRODITE criteria (Addressing male Patients with Hypogonadism and/or infeRtility Owing to altereD, Idiopathic TEsticular function) introduce a biologically rational fr…

ISRCTN23947730.

N/A.

N/A.

N/A.

Not applicable.