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Abstract Human serum amyloid A (SAA) is an apolipoprotein that predominantly associates with high-density lipoprotein (HDL) in the blood and participates in lipid metabolism. In addition, SAA serves as a precursor of amyloid fibrils that contribute to the development of AA amyloidosis. Chemical modifications of amyloidogenic proteins can influence the formation of amyloid fibrils. Recently, vario…

Most cases of malaria, one of the most dangerous and common tropical parasite infections, occur in developing nations. Recent years have seen the emergence of novel treatment techniques, and numerous medication candidates are currently undergoing clinical research. One noteworthy outcome of combining an artemisinin derivative with a companion medication (in this case, mefloquine) using an alterna…

This study presents a new series of sulfanyl derivatives of 1,2,4-triazole (7a–L), synthesized from 5-((4-isopropyl-3-methylphenoxy)methyl)-4-phenyl-4 H-1,2,4-triazole-3-thiol (5) and substituted alkyl halides (6a–L). A green synthetic approach was developed using rice husk water extract as a catalyst, highlighting the principles of sustainable chemistry. In addition, p-thymol, a naturally occurr…

A facile, green synthesis method for Ag–Co bimetallic nanoparticles was developed using chickpea sprout water extract as both the reducing and stabilizing agent. The phytochemical biomolecules in the sprout extract enabled seedless, one-pot synthesis of monometallic (Ag100, Co100) and three compositional bimetallic nanoparticles (Ag25Co75, Ag50Co50, Ag75Co25). Comprehensive characterization by UV…

This study aimed to examine the phytochemical composition and antiasthmatic effects of chloroform, methanol, and aqueous leaves extract of Caesalpinia crista L. (CC) using five experimental animal models. The bioactive compounds such as fatty acids, esters, ketones, dicarboxylic acids, and sugars were identified in CC leaves through qualitative phytochemical tests and Gas Chromatography-Mass Spec…

Electrochemical hydrogen production in alkaline media faces distinct mechanistic challenges compared with acidic conditions, largely due to the extra water dissociation step (Volmer reaction) and slower hydrogen adsorption and desorption kinetics. Non-noble electrocatalysts have attracted significant attention as cost-effective alternatives to platinum, offering a balance between activity, stabil…

Twenty-four new hybrid Pyrrole-tryptamines compounds were synthesized and thoroughly characterized using various techniques such as FT-IR, 1H NMR, 13C NMR, and LC-MS. An evaluation of each compound was conducted based on criteria including their PASS, BBB, ADME, pharmacophore model, and bioactive score. Antibacterial testing of all derivatives indicated that compound 5j exhibited strong activity …

This study presents a comprehensive analysis of four titanium (Tiₙ) clusters investigating their potential for CO₂ activation and conversion into valuable products such as formate, methanol, and methane. When the CO2 molecule adsorbed on bare Tin clusters it undergoes noticeable structural distortion, characterized by C–O bond elongation and O–C–O angle bending and charge transfer from the Tin cl…

The present work describes a systematic application of quality by design (QbD) based strategy for developing and validating a high-performance thin layer chromatography (HPTLC) method for qualitative evaluation of bempedoic acid in bulk and its pharmaceutical tablet dosage form. Toluene: Ethyl acetate: acetonitrile: glacial acetic acid (5:3:2:0.1 v/v/v/v) were chosen as the mobile phase, and Merc…

Multidrug resistance (MDR) in bacteria poses a major public health challenge, driven largely by efflux transporters such as the Escherichia coli multidrug transporter MdfA. As a proton-coupled antiporter belonging to the Major Facilitator Superfamily (MFS), MdfA harnesses the transmembrane proton gradient to expel structurally diverse toxic compounds. However, the molecular basis by which environ…

The high acidity in crude oil, often expressed as Total Acid Number (TAN), is corrosive; posing significant operational and economic challenges in refining crude oil. With the aim of deacidifying crude oil via TAN removal, biogenic, sustainable activated carbons (KAC) were designed via an initial carbonization of kitchen waste to biochar followed by its impregnation with KOH with subsequent activ…

Edible biomass and related wastes can be converted into useful porous carbons used in energy storage devices. Techniques like pyrolysis, carbonization, and chemical/physical activation create carbon materials with high surface area, tunable pore structures, and heteroatom doping. These materials demonstrate strong performance in supercapacitors and hybrid devices with excellent specific capacitan…

Herein, we report the synthesis of a dual-function azo dye, i.e. thiazole-resorcinol azo (TRA) dye. The synthesized dye, whose structure was confirmed by spectroscopic analysis, was used to modify a carbon paste electrode (thiazole-resorcinol azo dye modified carbon paste electrode, TRA/MCPE) for the simultaneous electrochemical detection of Dopamine (DA), Paracetamol (PA), and Tryptophan (TR). E…

The presence of microplastics (MPs) in marine, terrestrial, and atmospheric ecosystems, as well as in drinking water, has become a major environmental and public health concern. Coagulation has emerged as one of the most widely investigated techniques for removing MPs from water systems. Recent advancements in coagulation-based removal are summarized with emphasis on the various classes of coagul…

Nanosilica gels were synthesized by sol-gel route from Rice husk and Beach Sand, and characterized by XRD, FTIR, SEM, XRF, TEM, SAED and pHpzc techniques for batch adsorption of Cr(VI) ions, integrating molecular docking study of AY dye onto the adsorbents. The XRD spectra, and SAED images confirmed that the gels were polycrystalline, while TEM images revealed varying nanometric particle with dia…