Stability indicating HPTLC method development and validation of bempedoic acid in bulk and tablet dosage form by using AQbD approach

The present work describes a systematic application of quality by design (QbD) based strategy for developing and validating a high-performance thin layer chromatography (HPTLC) method for qualitative evaluation of bempedoic acid in bulk and its pharmaceutical tablet dosage form. Toluene: Ethyl acetate: acetonitrile: glacial acetic acid (5:3:2:0.1 v/v/v/v) were chosen as the mobile phase, and Merck HPTLC silica gel 60 F254 plates as the stationary phase. Derivatization with anisaldehyde-sulfuric