Design and synthesis of novel pyrrole coupled tryptamine derivatives as contenders against Staphylococcus aureus

Twenty-four new hybrid Pyrrole-tryptamines compounds were synthesized and thoroughly characterized using various techniques such as FT-IR, 1H NMR, 13C NMR, and LC-MS. An evaluation of each compound was conducted based on criteria including their PASS, BBB, ADME, pharmacophore model, and bioactive score. Antibacterial testing of all derivatives indicated that compound 5j exhibited strong activity against MRSA. Investigations into membrane damage, supported by SEM images, cellular content leakage,