Advanced Science

ABSTRACT Acinetobacter baumannii is an opportunistic pathogen with increasing resistance to conventional antibiotics, necessitating novel antimicrobial strategies. The outer membrane integrity of most Gram‐negative bacteria critically depends on the lipopolysaccharide (LPS) transport (Lpt) system, which mediates LPS translocation from the inner to the outer membrane. In this study, we perform a s…

ABSTRACT Immunotherapy has transformed the treatment of non‐small cell lung cancer (NSCLC), yet most patients fail to respond due to poorly understood resistance mechanisms. Here, integrative multi‐omics analysis combining single‐cell RNA‐sequencing, bulk RNA‐seq, and spatial transcriptomics is performed on tumors from NSCLC patients receiving immune checkpoint blockade (ICB). Transcriptomic prof…

ABSTRACT Despite considerable pathological diversity, pediatric sarcomas lack molecularly targeted treatments, demanding deeper pathobiological insights and innovative therapeutic strategies. Here, we demonstrate that overexpressed MDM2 functions as an important pathogenic driver in these malignancies, rewiring oncogenic programs through both p53‐independent chromatin occupancy to regulate active…

ABSTRACT Rapid and sensitive diagnostic strategies are crucial for the prevention and control of tuberculosis (TB). Unlike the invasive TB diagnostic strategy in the clinic, here we introduce a convenient, portable, and non‐invasive system that is constructed by Ag@Au nanoflower (NF) array‐based sensing facemask and catalytic/plasmonic urchin‐shaped Au─Ag embedded covalent organic framework (U@CO…

ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed re…

ABSTRACT Cancer vaccines have demonstrated initial effectiveness in the treatment of human cancers, still the low mutational burden, which leads to a deficiency of well‐characterized antigens expressed within tumors capable of mediating tumor rejection, poses a significant challenge in pancreatic cancer. Here, we introduce an ionic liquid ILvax for localized tumor administration, which elicits a …

ABSTRACT Adult stem cell therapies are advancing, yet inconsistent clinical benefit indicates that in vitro potency only partially predicts in vivo performance. Framing efficacy through a systems lens, this review integrates three interlocking levers: (i) cell‐intrinsic programs (tissue imprint, transcriptional/epigenetic state, senescence and metabolic fitness), (ii) microenvironmental constrain…

ABSTRACT The growing prevalence of age‐related limb loss underscores the need for prosthetic technologies that restore not only motor function but also authentic sensory feedback. Current prosthetic systems largely depend on sensory substitution or signal remapping, which fall short of replicating natural somatosensory signals. In this work, we develop a plant‐enhanced bionic mechanoreceptor that…

ABSTRACT Circadian rhythms coordinate physiology with the 24 h light‐dark cycle, and their disruption contributes to diseases spanning metabolic, cardiovascular, and neuropsychiatric domains. Whether the temporal coherence between wearable‐derived activity and temperature rhythms predicts long‐term health outcomes in free‐living humans remains unknown. Here, analyzing week‐long concurrent wrist‐w…

ABSTRACT Stimuli‐responsive soft materials capable of converting environmental and physiological stimuli into optical and electrical signals are highly attractive for information security, wearable sensing, and personalized healthcare management. Herein, we report biocompatible viologen‐crosslinked eutectogels derived from poly(hydroxyethyl acrylate) (poly‐HEA) and natural deep eutectic solvent c…

ABSTRACT Proteins exert sophisticated functions through stimulus‐responsive conformational changes. Mimicking this structural control and functional integration in synthetic, water‐soluble polymers has been a fundamental challenge, largely due to the conflict between charge repulsion and conformational order. Here, we report a peptidomimetic polyelectrolyte that overcomes this limitation, maintai…

ABSTRACT Prostate cancer (PCa) ranks among the most common and deadly malignancies worldwide. The clinical treatment of advanced prostate cancer is particularly challenging due to acquired drug resistance. Autophagy and lysosome‐related pathways are key drivers of this resistance. Targeting the lysosome represents a potential therapeutic strategy for PCa. In this study, we identified Heat Shock P…

ABSTRACT This study demonstrates that circadian rhythm disruption induced by night‐shift work is associated with elevated blood pressure in both murine models and human subjects. By integrating rodent and human epidemiological data, we identify mitochondrial dysfunction as the principal mechanistic contributor to this relationship. In mice, data were obtained at 4 and 10 weeks, with sampling perf…

ABSTRACT Achieving controlled synthesis of silicoaluminophosphate (SAPO) zeolites is critical for optimizing their catalytic performances, yet it remains difficult due to the complex coupling of synthesis variables and insufficient atomic‐level structural understanding. Herein, we systematically investigate the multi‐scale characterization and controllable synthesis of SAPO zeolites. We explore t…

ABSTRACT Developing water‐stable organic room‐temperature phosphorescence (RTP) materials remains a formidable challenge due to water‐induced quenching. Herein, we present a counter‐intuitive strategy to achieve water‐enhanced ultralong RTP via the in situ encapsulation of carbonyl‐based guests within a rigid hydrogen‐bonded organic framework (HOF). Unlike conventional systems where water acts as…

Lithium-sulfur (Li-S) batteries face low sulfur utilization and limited rate capability. Although electrolyte engineering is a key strategy for improving the conversion kinetics of lithium polysulfides (LiPS), achieving a balance between high energy density and high power density remains challenging. This study combines an ultra-low concentration electrolyte with a dual-functional hybrid organic …

Marburg virus (MARV) causes Marburg virus disease (MVD), a severe hemorrhagic fever associated with high morbidity and mortality. No specific antiviral therapies are currently approved for MVD, and viral pathogenesis, particularly the viral pathogenic factor(s) involved, remains poorly defined. Here, we demonstrated that MARV glycoprotein (GP) can induce rounding and detachment of adherent cells,…

Polypropylene (PP) is widely used in film capacitors but is limited by an intrinsic trade-off between dielectric permittivity and breakdown strength, capping energy density around 3 J cm^- ³. This limitation is overcome by introducing a liquid silicone rubber (LSR107) interphase and BaTiO₃ (BT, diameter 5 nm) nanofiller into PP via one-step melt extrusion, creating…

Injectable wet-adhesive hydrogels represent a promising approach for managing traumatic hemorrhage, yet their clinical translation is often hindered by excessive swelling and inadequate sealing stability. Herein, we report an injectable hydrogel (denoted as PACmC) with rapid coagulation, ultrahigh burst pressure tolerance, and low swelling properties for emergency hemostasis and long-term wound m…

Mixed protonic-electronic conductors (MPECs) have been developed to maximize static conductivity for electrochemical applications, but emerging applications that leverage proton-electron coupling (PEC) require dynamic conductivity control. To achieve this, we propose a "de-doping" strategy in a hydrogen-bonded coordination polymer {[Co(DMF)₂(H₂O)₂(bipy)](NO<sub>3<…