Advanced Science

ABSTRACT The electrooxidation of 5‐hydroxymethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA) is often limited by competitive adsorption between HMF and surface‐bound hydroxyl species (OH ads ), which governs both activity and selectivity, yet independent control over these interfacial adsorption processes remains a fundamental challenge. Here, we report a molecular design strategy that int…

ABSTRACT Organic electrochemical transistor (OECT) is a promising building block for bioelectronic and neuromorphic applications due to its high transconductance and low‐voltage operation. However, microstructural instability and irreversible electrochemical degradation of the organic mixed ionic‐electronic conductors (OMIECs) are still challenging to achieve high performance of OECTs. Here, we p…

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targeted sequencing was performed in 1953 sporadic cases from a Han Chinese cohort. A rare missense mutation, A773E in intr…

ABSTRACT The lysosomal storage disorder Fabry disease results from α‐galactosidase A deficiency, leading to excessive glycosphingolipid substrate accumulation, primarily globotriaosylceramide (Gb3). While the underlying molecular mechanisms remain elusive, multi‐systemic complications ultimately culminate in premature death, with heart failure being the leading cause of death. Current treatment o…

ABSTRACT Neuromorphic devices are bioinspired electronic systems that mimic key structures and functions of the nervous system, enabling integration and communication between living tissues and machines. This review examines how neuromorphic devices and computing are designed to emulate the structure, organization, and function of the nervous system. For neuromorphic devices, we first describe st…

ABSTRACT Atherosclerosis remains the leading cause of cardiovascular mortality, with elevated oxidized low‐density lipoprotein (oxLDL) as a key driver. oxLDL metabolism involves two critical steps: generation mediated by proprotein convertase subtilisin/kexin type 9 (PCSK9)‐induced LDLR degradation, and plaque uptake via lectin‐like oxLDL receptor‐1 (LOX‐1). Current PCSK9 inhibitors reduce oxLDL …

ABSTRACT This study investigates sulfur spillover, the spontaneous and rapid spread of sulfur over carbon surfaces at ambient temperature. The process is studied by small‐angle X‐ray scattering (SAXS), X‐ray radiography, and microcalorimetry from which a number of physicochemical properties are derived. The results confirm that sulfur immediately interacts with porous carbon upon mixing, with mos…

ABSTRACT Heat shock triggers stress granule (SG) formation, yet their dynamics in mammalian germ cells remain unclear. Through systematic analysis, we uncovered distinct heat shock granule (HSG) composition and stage‐specific assembly/disassembly in the mouse testis. Ribosome profiling revealed that germ cells selectively sustain translation of spermatogenic genes during heat shock. We identified…

ABSTRACT Dexterous hands and robotic manipulators are essential physical interfaces for interacting with diverse environments. Traditional methods seek creature‐like dexterity through structural biomimicry of biological systems, a strategy that results in increased mechanical complexity and control challenges due to the stacking of components. This study presents the BioflexBot, a functionally bi…

ABSTRACT Early diagnosis of acute kidney injury (AKI) and identification of effective therapeutics remain significant clinical challenges. Herein, we developed an activatable near‐infrared fluorescent nanoprobe (denoted PS‐QRC) by encapsulating a self‐amplifying fluorescent sensor (QRCy) within kidney‐targetable L ‐serine‐functionalized ultrasmall poly(amidoamine) (PAMAM‐Ser) dendrimers. Upon act…

ABSTRACT Both the timing and composition of food intake have gained recognition for their effects on circadian (daily) rhythms in mammals, however the mechanisms by which these effects are exerted are incompletely understood. The present studies focus on synchronization of circadian rhythms to the environmental light‐dark cycle, particularly re‐entrainment following a phase shift such as occurs w…

ABSTRACT Spinal cord injury (SCI) induces neuroinflammation predominantly mediated by microglia, thereby establishing a detrimental milieu that impedes neurological recovery. Extracellular vesicles (EVs) derived from umbilical cord mesenchymal stem cells (UCMSCs) possess considerable therapeutic potential; however, their clinical translation is constrained by insufficient bioactivity, poor target…

ABSTRACT Cells must preserve and rewrite transcriptional memory to maintain identity and adapt to stress, yet the physical mechanisms governing this process remain unclear. Recent work implicates genome geometry in encoding transcriptional memory, with nanoscopic chromatin packing domains (PDs) serving as structural units that stabilize or reprogram transcriptional states. One powerful, yet under…

ABSTRACT Artificial nanozymes, defined as nanomaterials that mimic enzyme‐like catalytic activity, emerge as adaptable tools for biomedical applications by uniting catalytic activity with structural stability and chemical versatility. Here, we introduce liquid gallium (Ga) as a catalytic center for nitric oxide (NO) generation and demonstrate its translation into a multifunctional coating. Ga nan…

ABSTRACT Bicontinuous materials comprise an interpenetrating network of two continuous phases, demonstrating great potential for overcoming diffusion limitations in applications such as catalysis and energy storage. Bicontinuous interfacially jammed emulsion gels (bijels) formed via solvent‐transfer induced phase separation (STrIPS) show particular promise because their constituent nanoparticles …

ABSTRACT The recent discovery of type‐II multiferroicity in monolayer indicated a new pathway for intrinsic magnetoelectric coupling in the two‐dimensional limit. However, whether this phenomenon is a unique feature of or a chemically tunable property of the broader material class has remained unresolved. Here, we demonstrate that type‐II multiferroicity in the nickel dihalides is tunable through…

ABSTRACT Leakage and flammability are two critical safety issues limiting the practical application of organic phase change materials. Herein, a facile catalyst/solvent‐free multicomponent reaction involving alcohols/amines/thiols, dimethyl phosphite, and benzaldehyde was developed to simultaneously address these drawbacks. The terminal phosphite groups endow intrinsic flame retardancy, while int…

ABSTRACT Liquid crystal polymer networks represent a fascinating and promising class of soft materials due to their inherent stimuli‐responsive contraction and expansion, the direction of which is determined by the alignment director. This unique feature makes liquid crystal networks a prime candidate for the development of chiral actuators, and this topic has seen a marked increase in interest d…

ABSTRACT The tumor immunosuppressive microenvironment severely impedes the efficacy of immunotherapy. An avalanche effect nanomodulator, L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles, activates immunotherapy and remodels the immunosuppressive microenvironment through cascade‐triggered ferroptosis and cuproptosis. Within the tumor microacidic environment, calciu…

ABSTRACT Metasurfaces with reconfigurable shapes have a stronger adaptability to complex environments. This paper designs a bamboo‐slip‐inspired conformal reconfigurable transmission metasurface system with splicing ability and scalability. Bamboo‐slip‐inspired subarrays are assembled on different support skeletons to form conformal metasurfaces of various shapes to adapt to wide‐angle beam cover…