ABSTRACT Acinetobacter baumannii is an opportunistic pathogen with increasing resistance to conventional antibiotics, necessitating novel antimicrobial strategies. The outer membrane integrity of most Gram‐negative bacteria critically depends on the lipopolysaccharide (LPS) transport (Lpt) system, which mediates LPS translocation from the inner to the outer membrane. In this study, we perform a structure‐based virtual screen against the Lpt system of Acinetobacter and identify a somatostatin oct