Journal of Nanobiotechnology

Abstract Chronic wound healing represents a significant clinical challenge, requiring multi-target intervention strategies due to the complex pathological microenvironment. Traditional Chinese Medicine (TCM) has a long wound care history and TCM-based hydrogels have evolved from single- to multi-component designs. However, existing reviews primarily focus on preparation methods, lacking a systema…

Abstract Introduction Effective myocardial regeneration following infarction remains a major clinical challenge due to the complex and dynamic pathological microenvironment. Current clinical management fails to adequately modulate the dynamic infarct microenvironment, where dysregulated inflammation and insufficient angiogenesis represent key therapeutic targets. Methods To address this challenge…

We investigated the interaction between the monocationic aromatic drug propranolol (PPL) and double-stranded DNA (dsDNA) to elucidate how small molecules can drive higher-order DNA frameworks and nanoparticles (NPs) formation. Single-molecule force spectroscopy with optical tweezers revealed that, at concentrations below 4 mM, PPL interacts with dsDNA through an intercalation-like mode, altering …

Abstract Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, with a median overall survival of only 14–16 months despite maximal safe resection, radiotherapy, and temozolomide. The blood–brain barrier, infiltrative growth pattern, and tumor microenvironment-mediated therapeutic resistance severely limit the efficacy of conventional and emerging therapies. Phototherapy, includ…