A spatiotemporally coordinated curcumin-based microneedle patch for SDF-1α delivery and synergistic myocardial infarction therapy
Xue-Yan Jiang·Gen He·Yang Yang·Da-Wei Tang·王志忠·Pei Huang·Fang-Zhen Wang·Shu-Meng Zhang·Hao-Min Zhang·Yi-Yun Ma·Xu-Chen Liu·Yun-Ru Li·Wenhua Zheng·Lingmin Zhang·Xi-Yong Yu·Yuan Luo
Abstract Introduction Effective myocardial regeneration following infarction remains a major clinical challenge due to the complex and dynamic pathological microenvironment. Current clinical management fails to adequately modulate the dynamic infarct microenvironment, where dysregulated inflammation and insufficient angiogenesis represent key therapeutic targets. Methods To address this challenge, we developed a spatiotemporally coordinated microneedle (MN) patch based on curcumin-conjugated gel