pharmaceutical-science

Researchers have developed a light-driven method for creating tiny, high-energy “housane” molecules that are valuable for drug development and materials science. These compact ring-shaped structures are difficult to produce because of the intense internal strain they contain. By using photocatalysis and carefully tuning the starting molecules, the team managed to guide the reaction into a clean a…

Fritillariae Cirrhosae Bulbus is a valuable and authentic medicinal material widely used in traditional Chinese medicine to treat respiratory diseases. Modern medical research shows that alkaloids, the main metabolites of Fritillariae Cirrhosae Bulbus, not only have expectorant and antitussive effects and can disperse swelling, but also have important clinical value and broad prospects for feed d…

Cryomicroneedles offer a route to minimally invasive intradermal delivery of living cells, but their cryogenic formulations must reconcile cell protection with constraints on toxicity and device fabrication. Here we report an AI-assisted, closed-loop workflow for cryomicroneedle cryoprotectant discovery that combines literature curation, Gaussian-process surrogate modelling, Bayesian optimization…

Chemists at University of Chicago have developed a new chemical technique that could make it much easier and faster to create future medicines. The breakthrough allows scientists to quickly modify molecules by replacing certain carbon-oxygen structures with nitrogen atoms. According to the researchers, this process could dramatically speed up drug discovery by reducing complicated chemical […] Th…

The present study aimed to develop Ketoconazole -loaded ethosomal gel intended to be applied topically for treating skin infections. Ethosomes were prepared using the cold method. The formulation variables were optimize dusing[3] factorial designand Design Expert® software for analyzing the data statistically and graphically using response surfaceplots. Phospholipid (X1) and ethanol (X2) and prop…

Poor water solubility is still one of the toughest problems in drug development today. It really limits how effective a lot of new drugs can be. Around 40–70% of new chemical compounds just don’t dissolve well in water. So, when you take them by mouth, they don’t break down enough in your gut, which means people absorb less of the drug, and the results can be unpredictable. This issue is especial…

The oral route is the most widely accepted method for drug administration due to its convenience and patient compliance. However, it faces significant challenges such as rapid gastric emptying and poor absorption of drugs with a narrow absorption window in the upper gastrointestinal tract. These limitations result in reduced bioavailability and inconsistent therapeutic outcomes. To address these …