Cochrane Database of Systematic Reviews

RATIONALE: Numerous media are commercially available for culture of human pre-implantation embryos in assisted reproductive technology (ART) cycles. It is unknown which culture medium leads to the best success rates after ART. This is the first update of a Cochrane review published in 2015. OBJECTIVES: To evaluate the benefits and harms of different human pre-implantation embryo culture media use…

RATIONALE: Extensive-stage small cell lung cancer (SCLC) carries a poor prognosis and has limited therapeutic options. The addition of immune-checkpoint inhibitors (ICIs) to platinum-etoposide (PE) chemotherapy has become an important first-line treatment strategy. However, the comparative benefits and harms of different first-line chemotherapy-based regimens, including ICI-containing combination…

BACKGROUND: Atherosclerotic peripheral arterial disease (PAD) can lead to chronic limb-threatening ischemia (CLTI) and limb loss. Treatments include lifestyle modifications, medications, and both open and minimally invasive operative approaches, including balloon angioplasty. Drug-eluting balloon (DEB) angioplasty is a promising alternative to uncoated balloon angioplasty for treating PAD. Balloo…

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To evaluate the benefits and harms of pharmacological treatments for uterine fibroids in women of reproductive age compared with placebo or no treatment, another pharmacological treatment or surgery.

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the clinical benefits and adverse effects of glucagon-like peptide-1 receptor agonist-based regimens, compared with metformin-based glucose-lowering regimens, for preventing cardiovascular events including all-cause mortality, cardiovascular mortality, non-fatal myocardial infarction, non…

RATIONALE: Post-stroke dysphagia ((PSD) impaired swallowing following stroke), increases risk of death, yet the effects of potential treatments are unclear. This review updates the 2018 review. OBJECTIVES: To assess the effects of swallowing therapies on swallowing impairment (SI) among stroke survivors with dysphagia, within six months of stroke onset. SEARCH METHODS: We searched MEDLINE, Embase…

RATIONALE: Evidence guiding how often adults with type 1 diabetes mellitus should self-monitor blood glucose, when to monitor, and which glycaemic targets to use is limited and inconsistent. The available research has not clearly linked different self-monitoring strategies to meaningful clinical outcomes, and evidence is particularly scarce for low-resource settings. Clarifying these uncertaintie…

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of faecal microbiota transplantation for treating steroid-refractory, acute lower gastrointestinal graft-versus-host disease in recipients of allogeneic haematopoietic stem cell transplantation, compared with standard care, observation, placebo, or other comparato…

RATIONALE: Embryo transfer (ET) is the final and most vulnerable step in in vitro fertilisation (IVF) treatment. Pregnancy rates after ET may be influenced by several factors, including straightening the utero-cervical angle, cervical and endometrial preparation, and techniques for traversing the cervix. Recent research has focused on improving the ET technique in the hope of increasing IVF succe…

Recurrence is probably more likely after native tissue repair than with biological graft or absorbable synthetic mesh at one to two years. We found no data for surgery for stress urinary incontinence. Anterior native tissue repair likely increases awareness of prolapse, recurrence and surgery for prolapse compared with transvaginal anterior permanent mesh repair. It is likely that fewer women rep…

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary Objective i) To assess the effects of cognitive behavioural therapy for insomnia (CBT-I) and cognitive behavioural therapy for menopausal symptoms (CBT-M) on sleep disturbances in women in perimenopause through to the early postmenopausal period. Secondary Objectives i) To assess the effects of CBT-I a…

None REGISTRATION: Protocol (2018) available via https://www.crd.york.ac.uk/PROSPERO/view/CRD42018116290 Original review (2019) DOI: 10.1002/14651858.CD013336.