Mapping where mouse models match — and miss — human tumor immunity

Nature Immunology, Published online: 21 May 2026; doi:10.1038/s41590-026-02527-1 A systematic comparison of the tumor microenvironment (TME) in mouse models and humans reveals that widely used models capture only a limited subset of the cellular diversity and cell type-specific gene expression observed in human TMEs. We present a resource that defines the conserved and divergent features, including shared gene programs, across mouse and human TMEs to guide model selection and improve the transla