DepoCatalog: mapping diversity of 129 recombinantly produced Klebsiella phage depolymerases
Zuzanna Drulis-Kawa
Nature Communications, Published online: 22 May 2026; doi:10.1038/s41467-026-73570-7 Phages can use enzymes (depolymerases) that degrade capsular polysaccharides to initiate infection of their bacterial hosts. Here, the authors characterize a diverse set of 129 Klebsiella phage depolymerases, defining five enzyme classes, revealing cross-reactivity, and linking enzyme’s specificity to structure.