Survival outcomes, determinants, and hemodynamic trajectories with intravenous β1-selective blockade in septic shock complicated by tachyarrhythmia: a real-world MIMIC-IV cohort study
Huixian Li
BackgroundSepsis and septic shock impose severe cardiovascular stress characterized by sympathetic overactivation and detrimental tachycardia, which is strongly linked to poor outcomes. While ultra-short-acting β1-blockers have shown promise in controlled trials for heart rate (HR) control, a critical gap remains regarding the optimal β1-selective regimen for complex, multimorbid, vasopressor-dependent patients with septic shock complicated by tachyarrhythmia in real-world settings.ObjectiveTo c