Clinical efficacy and gut microbiota profiling by 16S rRNA sequencing in children with Henoch–Schönlein purpura treated with integrated Chinese and Western medicine
Linqun Wang
BackgroundHenoch–Schönlein purpura (HSP) is the most common systemic vasculitis in children. Recent studies have suggested that gut microbiota dysbiosis may contribute to its pathogenesis, but microbial alterations and treatment-related changes remain unclear.MethodsA total of 142 children were initially enrolled, including 103 HSP patients and 39 healthy controls. After excluding 30 patients due to incomplete follow-up, 112 participants were included in the final clinical analysis: 39 healthy c