The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
Craig M. Crews
Nature Cell Biology, Published online: 30 April 2026; doi:10.1038/s41556-026-01936-6 Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1.