Sinomenine ameliorates rheumatoid arthritis in rodent models: a systematic review and meta-analysis of anti-inflammatory and joint-protective effects
Jin-Liang Gao
ObjectiveThis systematic review and meta-analysis synthesize preclinical evidence to evaluate the therapeutic efficacy of sinomenine in rodent models of rheumatoid arthritis, and integrate current understanding of its potential mechanisms. This study aims to provide preclinical evidence and mechanistic insights to guide the clinical development of sinomenine for rheumatoid arthritis.MethodsThrough the systematic search of 4 English and 4 Chinese databases up to November 2025, qualified studies w