BackgroundCentral line-associated bloodstream infections (CLABSIs) are among the most serious healthcare-associated infections in intensive care units (ICUs), contributing to increased morbidity, mortality, and healthcare burden. However, evidence regarding the epidemiology and outcomes of CLABSI in Saudi Arabian ICUs remains limited. This systematic review and meta-analysis aimed to evaluate the incidence, microbiology, and clinical outcomes of CLABSI among ICU patients in Saudi Arabia.MethodsA