Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Aaron M. Newman
Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10452-4 Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments.