BackgroundStudies have shown that dysregulation of the gut microbiota (GM) plays a crucial role in the development of endometriosis (EMs). Study aimed to investigate the potential of protective GM metabolites in treating EM through network pharmacology and Mendelian randomization (MR), opening new avenues for targeted therapeutic strategies.MethodsAll data were sourced from publicly available databases. Biomarkers linked to protective GM metabolites in EMs were identified employing MR study (wit