Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4
H. Th. Marc Timmers
Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72319-6 X‑linked dystonia‑parkinsonism involves disrupted transcription and mRNA processing. Here, the authors show that altering 3′ mRNA processing rescues the disease molecular signature, linking XDP pathology to a non‑canonical function of the transcriptional regulator BRD4.