Parsing autism spectrum heterogeneity through fMRI

Nature Neuroscience, Published online: 15 May 2026; doi:10.1038/s41593-026-02269-1 Autism is remarkably heterogeneous, posing a long-standing challenge for linking genetics to brain dynamics. A cross-species study identifies two principal dysconnectivity signatures across 20 mouse models of autism risk, each associated with distinct molecular pathways, and shows analogous connectivity patterns in autistic humans. These results establish a translational framework for biologically grounded fMRI ph